What are the possible reasons why multi-vitamin pills used in clinical trials had no significant effects on reducing chronic diseases according to recent reports?
1) They are not readily absorbed by the body and if they do get into the bloodstream are not present in physiologically relevant dose to have any health effects.
2) There is no accurate measure of bioactivity to determine whether vitamins still have biological effects upon ingestion or whether digestion has inactivated them.
3) The purified synthetic form of vitamins and minerals as formulated in multi-vitamin pills may have structural and functional differences from its natural forms which are usually found in complex with other food components.
4) There is over reliance on antioxidant capacity as mechanism of action to explain health benefits of multivitamins and dietary supplements which is unpredictable and deemed unreliable by the USDA.
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